How does an OxyCodone high feel?
The active substance Oxycodone is a strong pain reliever (analgesic) belonging to the opioid class. Opioids in general are the strongest and safest pain relievers available. Oxycodone is made semi-synthetically, and its analgesic effect exceeds that of morphine, a natural opioid found in the opium poppy. Here you can read everything you need to know about the effects, side effects and use of oxycodone.
This is how oxycodone works
Pain is triggered by a painful stimulus such as an injury or inflammation. Information about the severity and location of the pain is transmitted to the brain via peripheral nerves and the spinal cord. Only then does the conscious pain perception take place.
Opioids have the ability to block this central perception of pain and are therefore used as analgesics (pain relievers). Some opioids are made synthetically, such as oxycodone, fentanyl, and methadone. Others are of natural origin such as morphine, obtained from the dried milky sap of the opium poppy (opium). Opioids can also be produced and released naturally by the body (the body's own endorphins).
Uptake and breakdown of oxycodone
Almost all of the active ingredient in an oxycodone tablet (around 60 to 85 percent) is absorbed into the body's bloodstream. The analgesic effect occurs in about 60 minutes and generally lasts for about four hours. In contrast, preparations with a prolonged effect work for eight to twelve hours. Oxycodone is finally broken down by enzymes in the liver (CYP450 2D6 / 3A4 enzyme) and excreted via the kidneys.
When is oxycodone used?
Oxycodone is one of the very strong pain relievers; it is more effective than morphine and is used in the treatment of severe and severe pain, such as:
- Pain due to damage to or disorder of the nervous system (neuropathic pain)
- Pain as a result of cancer (including in older children)
This is how oxycodone is used
Oxycodone is only used to treat severe pain. The active ingredient is usually taken as a tablet or capsule (orally). It can also be given directly into the vein as an intravenous injection. At the beginning of a treatment, the patient usually receives the pain reliever twice a day. However, it is possible to increase the dosage later if necessary.
The preparations usually contain the active ingredient in the form of salts as oxycodone HCl. The active ingredient is mixed with a so-called hydrochloride. The salt form of an active ingredient is necessary in the manufacture of pharmaceuticals.
What are the side effects of oxycodone?
Oxycodone cannot be taken any number of times depending on the pain sensation. The dosage is naturally limited by the occurrence of side effects.
Very common with the use of opioids such as oxycodone:
The following side effects rarely occur:
Central side effects such as hallucinations, confusion, vomiting and nausea are less common with oxycodone than with other opioids.
If taken regularly, tolerance to oxycodone can develop, so the pain reliever loses its effectiveness. This means that the dosage has to be increased in order to achieve the same analgesic effect as at the beginning of the treatment.
Physical dependence may develop with prolonged use of high doses of oxycodone. This can be problematic, especially with chronic (long-term) pain therapy. You should therefore not suddenly stop taking the pain reliever. Otherwise, withdrawal symptoms such as sweating, rapid heartbeat (tachycardia) and psychomotor restlessness would occur.
When should you not take oxycodone?
Oxycodone is not suitable as a pain reliever for children under 12 years of age. You should also avoid taking painkillers during pregnancy and while breastfeeding.
Oxycodone is not to be used in:
How to get oxycodone medication
Oxycodone is a strong opioid pain reliever and is therefore subject to the Narcotics Act. It can only be prescribed by a doctor on narcotic prescriptions and obtained from the pharmacy.
In order to counteract the very common side effect of constipation (constipation), the active ingredient is often combined with the so-called naloxone. However, this combination is not suitable for children.
Since when has oxycodone been known?
Since 1998 Oxycodone in Germany for pain therapy in the form of tablets on the market. It was only approved for direct injection (IV application) into the vein in 2006.
Author & source information
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